JOINT FILER INFORMATION
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NAME: Frost Gamma Investments Trust

ADDRESS: 4400 Biscayne Blvd
Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer and Ticker Symbol: Opko Health, Inc. (OPK)

Date of Event Requiring Statement: September 6, 2007



FROST GAMMA INVESTMENTS TRUST

by: /s/ Phillip Frost MD
Phillip Frost, M.D., Trustee