Form: 4/A

Statement of changes in beneficial ownership of securities

March 30, 2007

FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Frost Gamma Investment Trust
   2. Issuer Name and Ticker or Trading Symbol
eXegenics Inc [EXEG] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
4400 BISCAYNE BOULEVARD, 15TH FLOOR		 3. Date of Earliest Transaction (Month/Day/Year)
03/27/2007
(Street)

MIAMI, FL 33137		 4. If Amendment, Date Original Filed(Month/Day/Year)
03/29/2007		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/27/2007   A   36,518,923 A (1) 36,518,923 D  
Common Stock               15,490,546 I See Footnote (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrants (Right to Buy) $ 0.6728 03/27/2007   A   3,080,529     (3) 03/27/2017 Common Stock 3,080,529 (1) 3,080,529 D  
Warrants (Right to Buy) $ 0.8473 03/27/2007   A   3,080,530     (3) 03/27/2017 Common Stock 3,080,530 (1) 3,080,530 D  
Warrants (Right to Buy) $ 1.0466 03/27/2007   A   3,080,530     (3) 03/27/2017 Common Stock 3,080,530 (1) 3,080,530 D  
Warrants (Right to Buy) $ 0.4984 03/27/2007   A   4,000,000     (3) 03/27/2017 Common Stock 4,000,000 (4) 4,000,000 I See Footnote (2)
Warrants (Right to Buy) $ 0.0002 03/27/2007   A   81,085     (3) 01/17/2011 Common Stock 81,085 (5) 81,085 I See Footnote (2)
Warrants (Right to Buy) $ 38.54 03/27/2007   A   6,487     (3) 01/11/2017 Common Stock 6,487 (5) 6,487 I See Footnote (2)
Warrants (Right to Buy) $ 0.672 03/27/2007   A   22,124     (3) 03/27/2017 Common Stock 22,124 (5) 22,124 I See Footnote (2)
Warrants (Right to Buy) $ 0.8473 03/27/2007   A   22,124     (3) 03/27/2017 Common Stock 22,124 (5) 22,124 I See Footnote (2)
Warrants (Right to Buy) $ 1.0467 03/27/2007   A   22,125     (3) 03/27/2017 Common Stock 22,125 (5) 22,125 I See Footnote (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Frost Gamma Investment Trust
4400 BISCAYNE BOULEVARD
15TH FLOOR
MIAMI, FL 33137		     X    

Signatures

 /s/ Frost Gamma Investments Trust   03/29/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The reporting person acquired these securities in connection with the merger of Froptix Corporation into a wholly-owned subsidiary of the issuer in exchange for securities of Froptix held by the reporting person immediately before the merger. On the effective date of the merger the closing sales price of the issuer's common stock was $3.28.
(2) These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group. Frost Gamma Investments Trust disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
(3) These warrants are immediately exercisable.
(4) These warrants were acquired by The Frost Group as part of the consideration paid by the issuer for a line of credit extended by The Frost Group to the issuer in connection with the merger.
(5) The Frost Group acquired these securities in connection with the merger of Acuity Pharmaceuticals, Inc. into a wholly-owned subsidiary of the issuer in exchange for securities of Acuity held by The Frost Group immediately before the merger. On the effective date of the merger the closing sales price of the issuer's common stock was $3.28 per share.

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