Form: 3

Initial statement of beneficial ownership of securities

July 24, 2020

FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Hernandez Rulfo Fernando
 2. Date of Event Requiring Statement (Month/Day/Year)
07/22/2020		 3. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [OPK]
(Last)
(First)
(Middle)
4400 BISCAYNE BLVD.		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
CAO, Treasurer
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MIAMI, FL 33137		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 87
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (1) 06/11/2024 Common Stock 40,000 $ 9.1 D  
Stock Option (Right to Buy)   (2) 03/17/2025 Common Stock 60,000 $ 14.42 D  
Stock Option (Right to Buy)   (3) 03/31/2026 Common Stock 75,000 $ 10.41 D  
Stock Option (Right to Buy)   (4) 06/20/2028 Common Stock 50,000 $ 4.46 D  
Stock Option (Right to Buy)   (5) 06/30/2029 Common Stock 100,000 $ 2.47 D  
Stock Option (Right to Buy)   (6) 06/03/2030 Common Stock 100,000 $ 2.27 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Hernandez Rulfo Fernando
4400 BISCAYNE BLVD.
MIAMI, FL 33137		       CAO, Treasurer  

Signatures

Rulfo F. Hernandez 07/24/2020
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option will vest in four equal annual installments beginning June 12, 2015.
(2) This option will vest in four equal annual installments beginning March 18, 2016.
(3) This option will vest in four equal annual installments beginning April 1, 2017.
(4) This option will vest in four equal annual installments beginning June 21, 2019.
(5) This option will vest in four equal annual installments beginning July 1, 2020.
(6) This option will vest in four equal annual installments beginning June 4, 2021.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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