Form: EFFECT

Notice of Effectiveness

April 26, 2012

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: April 26, 2012
Accession Number: 0001193125-12-125664
Submission Type: POS AM
CIK: 0000944809
Company Name: Opko Health, Inc.
File Number: 333-177962