OPKO Health Announces Listing in Major Indices on Tel Aviv Stock Exchange

Provides Broader Access to Israeli Investors for Shares already listed on NYSE and TASE under Ticker Symbol OPK

MIAMI--(BUSINESS WIRE)-- OPKO Health, Inc. (NYSE: OPK), a multi-national biopharmaceutical and diagnostics company, today announced that OPKO's common stock, which began trading on the Tel-Aviv Stock Exchange ("TASE") on August 21, 2013, will be included, effective October 6, 2013, in the following major TASE indices: Tel Aviv 25, Tel Aviv 100, Tel Aviv Composite, Tel Aviv Biomed, and Tel Aviv BlueTech-50.

“OPKO’s inclusion in these major TASE indices expands our exposure to Israel’s vibrant investment community and its large and sophisticated investors,” commented Dr. Phillip Frost, OPKO’s Chairman and Chief Executive Officer. “Our participation in these major indices conveys broader coverage through index-based instruments, exchange traded notes, funds and specialized funds, while providing easier access to institutional and private investors within the Israeli market."

OPKO will remain subject to the rules and regulations of the NYSE and of the U.S. Securities and Exchange Commission. Trading on the TASE occurs on Sunday from 9:45 AM to 4:30 PM Israel time and on Monday through Thursday from 9:45 AM to 5:30 PM Israel time, except on TASE trading holidays. Through the amendment to Israel's Securities Law 5728-1968, that took effect in October 2000, U.S.-listed companies may dual-list on the TASE without any additional regulatory requirements. TASE links to the U.S. markets via a direct link to DTC, a subsidiary of the Depository Trust & Clearing Corporation, which facilitates the trading of dually-listed securities.

ABOUT OPKO HEALTH, INC.

OPKO is a multinational biopharmaceutical and diagnostics company that seeks to establish industry leading positions in large, rapidly growing markets by leveraging its discovery, development and commercialization expertise and novel and proprietary technologies. For more information, visit http://www.opko.com.

SAFE HARBOR STATEMENT

This press release includes forward looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995, which are subject to risk and uncertainties that could cause actual results to differ materially from those anticipated. Such statements may relate to OPKO's plans, objectives and expected financial and operating results, including statements regarding our ability to expand our exposure to the Israeli investment community and increase interest in OPKO among Israel's large and sophisticated institutional investors. The words "may," "could," "would," "will," "believe," "anticipate," "estimate," "expect," "intend," "plan," and similar expressions or variations thereof are intended to identify forward-looking statements. Investors are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, many of which are beyond OPKO's ability to control. The risks and uncertainties that may affect forward looking statements include, but are not limited to: currency fluctuations, global economic and political conditions, marketing demand for OPKO's products and services, long sales cycles, new product development, assimilating future acquisitions, maintaining relationships with customers and partners, and increased competition, as well as the risk we may not complete the acquisition of PROLOR Biotech, Inc. For more details about the risks and uncertainties related to OPKO's business, refer to OPKO's filings with the Securities and Exchange Commission. OPKO undertakes no obligation to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise.

OPKO Heath, Inc.
Steve D. Rubin, +1-305-575-4100
Executive Vice President — Administration
or
Juan F. Rodriguez, +1-305-575-4100
Chief Financial Officer

Source: OPKO Heath, Inc.

Released August 28, 2013