Form: 10-K

Annual report pursuant to Section 13 and 15(d)

March 1, 2022


Exhibit 21
SUBSIDIARIES OF OPKO HEALTH, INC.
 
NAME    JURISDICTION OF INCORPORATION
OPKO Instrumentation, LLC    Delaware
OPKO Pharmaceuticals, LLC    Delaware
OPKO Diagnostics, LLC    Delaware
OPKO Chile, S.A.    Chile
Arama Natural Products Distribuidora, Ltda Chile
Pharmacos Exakta S.A. de C.V.    Mexico
FineTech Pharmaceutical Ltd    Israel
OPKO Health Europe, S.L.    Spain
OPKO Biologics, Ltd Israel
OPKO Ireland Global Holdings, Ltd Ireland
OPKO Ireland, Ltd Ireland
OPKO Canada Corp, ULC Canada
OPKO Renal, LLC Canada
Curna, Inc. Delaware
BioReference Laboratories, Inc. New Jersey
GeneDX, Inc. New Jersey
Genome Diagnostics, Ltd Canada
EirGen Pharma Limited Ireland
Transition Therapeutics, Inc. Canada