Form: 10-Q/A

Quarterly report pursuant to Section 13 or 15(d)

July 5, 2011

Exhibit 31.4
CERTIFICATIONS
I, Rao Uppaluri, certify that:
  (1)   I have reviewed this Quarterly Report on Form 10-Q of OPKO Health, Inc.;
 
  (2)   Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
         
     
Date: July 5, 2011  /s/ Rao Uppaluri    
  Rao Uppaluri   
  Chief Financial Officer