Exhibit 16.1

Rotenberg & Co., LLP
Certified Public Accountants

April 11, 2007

Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549

Dear Ladies and Gentlemen:

We have read Item 4.01 of Form 8-K dated April 9, 2007 of eXegenics Inc. and are in agreement with the statements regarding Rotenberg & Co., LLP contained therein.