Form: 4

Statement of changes in beneficial ownership of securities

February 7, 2008

JOINT FILER INFORMATION
 
 
NAME:   Frost Gamma Investments Trust
 
ADDRESS:  
4400 Biscayne Blvd
Miami, FL 33137
 
Designated Filer:   Phillip Frost, M.D.
 
Issuer and Ticker Symbol:    Opko Health, Inc. (OPK)
 
Date of Event Requiring
Statement:
 
February 5, 2008
 
 
 
FROST GAMMA INVESTMENTS TRUST
 
 
by:
/s/ Phillip Frost MD, as trustee
  Phillip Frost, M.D., Trustee