Form: 4

Statement of changes in beneficial ownership of securities

February 22, 2008


JOINT FILER INFORMATION


   
NAME:
Frost Gamma Investments Trust
   
ADDRESS:
4400 Biscayne Blvd
 
Miami, FL 33137
   
Designated Filer:
Phillip Frost, M.D.
   
Issuer and Ticker Symbol:
Opko Health, Inc. (OPK)
   
Date of Event Requiring
 
Statement:
February 20, 2008
 
 
 
 
 
 
 
 
     
FROST GAMMA INVESTMENTS TRUST
 
 
 
 
 
 
  by:   /s/ Phillip Frost MD, as trustee
 
Phillip Frost, M.D., Trustee