Form: 4

Statement of changes in beneficial ownership of securities

April 8, 2008


JOINT FILER INFORMATION

 
NAME:
 
Frost Gamma Investments Trust
     
ADDRESS:
 
4400 Biscayne Blvd
   
Miami, FL 33137
     
Designated Filer:
 
Phillip Frost, M.D.
     
Issuer and Ticker Symbol:
 
Opko Health, Inc. (OPK)
     
Date of Event Requiring Statement:
 
April 8, 2008
 
FROST GAMMA INVESTMENTS TRUST

 
by:
/s/ Phillip Frost MD, as trustee
 
   
Phillip Frost, M.D., Trustee