Form: 4

Statement of changes in beneficial ownership of securities

April 11, 2008

JOINT FILER INFORMATION

NAME:
Frost Gamma Investments Trust
   
ADDRESS:
4400 Biscayne Blvd
 
Miami, FL 33137
   
Designated Filer:
Phillip Frost, M.D.
   
Issuer and Ticker Symbol:
Opko Health, Inc. (OPK)
   
Date of Event Requiring Statement:
April 9, 2008


FROST GAMMA INVESTMENTS TRUST

by:  /s/ Phillip Frost MD, as trustee
Phillip Frost, M.D., Trustee