Form: 4

Statement of changes in beneficial ownership of securities

April 15, 2008


JOINT FILER INFORMATION




NAME:
Frost Gamma Investments Trust
   
ADDRESS:
4400 Biscayne Blvd
 
Miami, FL 33137
   
Designated Filer:
Phillip Frost, M.D.
   
Issuer and Ticker Symbol:
Opko Health, Inc. (OPK)
   
Date of Event Requiring Statement:
April 11, 2008
 

FROST GAMMA INVESTMENTS TRUST
 
       
 
by:
/s/ Phillip Frost MD, as trustee
 
   
Phillip Frost, M.D., Trustee