Form: 4

Statement of changes in beneficial ownership of securities

August 1, 2008


JOINT FILER INFORMATION
 
Name:
 
Frost Gamma Investments Trust
     
Address:
 
4400 Biscayne Blvd
   
Miami, FL 33137
     
Designated Filer:
 
Phillip Frost, M.D.
     
Issuer Name and Ticker Symbol:
 
OPKO Health, Inc. (OPK)
     
Date of Earliest Transaction:
 
July 30, 2008
     
Relationship to Issuer:
 
10% Owner

FROST GAMMA INVESTMENTS TRUST

 
by:
/s/ Phillip Frost MD, as trustee
   
Phillip Frost, M.D., Trustee