Published on October 3, 2008
JOINT FILER INFORMATION
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Name: Frost Gamma Investments Trust
Address: 4400 Biscayne Blvd
Miami, FL 33137
Designated Filer: Phillip Frost, M.D.
Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)
Date of Earliest Transaction: October 2, 2008
Relationship to Issuer: 10% Owner
FROST GAMMA INVESTMENTS TRUST
by: /s/ Phillip Frost MD, as trustee
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Phillip Frost, M.D., Trustee