JOINT FILER INFORMATION


Name: Frost Gamma Investments Trust

Address: 4400 Biscayne Blvd
Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: February 6, 2009

Relationship to Issuer: 10% Owner



FROST GAMMA INVESTMENTS TRUST

by: /s/ Phillip Frost MD, as trustee
--------------------------------
Phillip Frost, M.D., Trustee