JOINT FILER INFORMATION
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Name: Frost Gamma Investments Trust

Address: 4400 Biscayne Blvd
Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: February 23, 2009

Relationship to Issuer: 10% Owner



FROST GAMMA INVESTMENTS TRUST

by: /s/ Phillip Frost MD, as trustee
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Phillip Frost, M.D., Trustee