Form: 4

Statement of changes in beneficial ownership of securities

June 19, 2009


JOINT FILER INFORMATION


Name:
Frost Gamma Investments Trust
   
Address:
4400 Biscayne Blvd
 
Miami, FL 33137
   
Designated Filer:
Phillip Frost, M.D.
   
Issuer Name and Ticker Symbol:
OPKO Health, Inc. (OPK)
   
Date of Earliest Transaction:
June 18, 2009
   
Relationship to Issuer:
10% Owner



FROST GAMMA INVESTMENTS TRUST

 
by:
/s/ Phillip Frost MD, as trustee
 
Phillip Frost, M.D., Trustee