JOINT FILER INFORMATION




NAME: 			Frost Gamma Investments Trust


ADDRESS:			4400 Biscayne Blvd
				Miami, FL 33137


Designated Filer:		Phillip Frost, M.D.


Issuer and Ticker Symbol: 	Opko Health, Inc. (OPK)


Date of Event Requiring
Statement:			December 4, 2007







FROST GAMMA INVESTMENTS TRUST

	by:	/s/ Phillip Frost, M.D., Trustee
		________________________________

		Phillip Frost, M.D., Trustee