Form: 10-K

Annual report pursuant to Section 13 and 15(d)

March 18, 2013

Documents

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

 

  1. Registration Statement (Form S-1 No. 333-177962) of OPKO Health, Inc. and subsidiaries,

 

  2. Registration Statement (Form S-3 No. 333-172168) of OPKO Health, Inc. and subsidiaries, and

 

  3. Registration Statement (Form S-8 No. 333-144040) of OPKO Health, Inc. and subsidiaries;

of our reports dated March 18, 2013, with respect to the consolidated financial statements of OPKO Health, Inc. and subsidiaries and the effectiveness of internal control over financial reporting of OPKO Health, Inc. and subsidiaries included in this Annual Report (Form 10-K) of OPKO Health, Inc. and subsidiaries for the year ended December 31, 2012.

/s/ Ernst & Young LLP

Certified Public Accountants

Miami, Florida

March 18, 2013