JOINT FILER INFORMATION

Name:	Frost Gamma Investments Trust

Address:
4400 Biscayne Blvd.
	Miami, FL  33137

Designated Filer:	Phillip Frost, M.D.

Issuer Name and Ticker Symbol:	OPKO Health, Inc. (OPK)

Date of Earliest Transaction:	September 20, 2016

Relationship to Issuer:	10% Owner


FROST GAMMA INVESTMENTS TRUST

	By:	/s/ Phillip Frost, M.D., as Trustee
	Phillip Frost, M.D., Trustee