EX-99 DOCUMENT
Published on January 2, 2019
JOINT FILER INFORMATION Name: Frost Nevada Investments Trust Address: 4400 Biscayne Blvd. Miami, FL 33137 Designated Filer: Phillip Frost, M.D. Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK) Date of Earliest Transaction: December 31, 2018 Relationship to Issuer: 10% Owner FROST NEVADA INVESTMENTS TRUST By: /s/ Phillip Frost, M.D., as Trustee Phillip Frost, M.D., Trustee