Exhibit 31.3

CERTIFICATIONS

I, Phillip Frost, certify that:

	(1)		I have reviewed this Annual Report on Form 10-K/A of OPKO Health, Inc.;
	(2)		Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;