Table of Contents

SECURITIES AND EXCHANGE COMMISSION

FORM 8-K/A

Date of Report (Date of earliest event reported) September 17, 2003

eXegenics Inc.

2110 Research Row
Dallas, Texas 75235

(Address of principal executive
offices including zip code)

(214) 358-2000

(Registrant’s telephone number,
including area code)

N.A.

Table of Contents

Item 4. Changes in Registrant’s Certifying Accountant.

As previously reported, on September 17, 2003, eXegenics Inc. (the “Registrant”) was advised by Ernst & Young LLP (“E&Y”) that E&Y was resigning as the Registrant’s independent auditor.

On November 11, 2003, based upon the recommendation of the Registrant’s Audit Committee and the approval of the Registrant’s Board of Directors, the Registrant engaged BDO Seidman, LLP as the Registrant’s independent auditor for the fiscal year ended December 31, 2003.

During the fiscal years ended December 31, 2001 and 2002 and the subsequent interim period through November 11, 2003, BDO Seidman, LLP was not engaged as the Registrant’s principal accountant to audit the Registrant’s financial statements nor was it consulted regarding any of the matters or events set forth in Item 304(a)(2)(i) and (ii) of Regulation S-K.

Item 5. Other Events and Regulations FD Disclosure.

On November 12, 2003, the Registrant issued a press release announcing the engagement of BDO Seidman, LLP. A copy of the press release is filed herewith as Exhibit 99.1 and incorporated herein by reference.

Item 7. Financial Statements, Pro Forma Financial Information and Exhibits.

(a) Exhibits

99.1  Press Release of eXegenics Inc., dated November 12, 2003.

Table of Contents

SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Table of Contents

INDEX TO EXHIBITS