Form: 10-K

Annual report pursuant to Section 13 and 15(d)

March 16, 2009

Exhibit 21
SUBSIDIARIES OF OPKO HEALTH, INC.
     
NAME   JURISDICTION OF INCORPORATION
 
   
OPKO Instrumentation, LLC
  Delaware
OPKO Ophthalmics, LLC
  Delaware
Froptix LLC
  Florida
Ophthalmics Technology, Inc.
  Ontario, Canada
Vidus Ocular, Inc.
  Delaware